Design, synthesis and molecular modelling of new bulky Fananserin derivatives with altered pharmacological profile as potential antidepressants

Przemysław Zaręba; Jolanta Jaśkowska; Izabela Czekaj; Grzegorz Satała

doi:10.1016/j.bmc.2019.06.028

Design, synthesis and molecular modelling of new bulky Fananserin derivatives with altered pharmacological profile as potential antidepressants

Bioorg Med Chem. 2019 Aug 1;27(15):3396-3407. doi: 10.1016/j.bmc.2019.06.028. Epub 2019 Jun 21.

Authors

Przemysław Zaręba¹, Jolanta Jaśkowska², Izabela Czekaj², Grzegorz Satała³

Affiliations

¹ Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska Street, Cracow 31-155, Poland. Electronic address: pzareba@indy.chemia.pk.edu.pl.
² Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska Street, Cracow 31-155, Poland.
³ Department of Medicinal Chemistry, Institute of Pharmacology - Polish Academy of Sciences, 12 Smętna Street, Cracow 31-343, Poland.

PMID: 31253535
DOI: 10.1016/j.bmc.2019.06.028

Abstract

It is now known that many neurotransmitter systems are responsible for diseases of the central nervous system (CNS). One of the most common CNS disease is depression. Considering that in the treatment and the genesis of depression, the most important are the serotonin receptors from 5-HT_1A, 5-HT_2A, 5-HT₆ and 5-HT₇ groups, and dopamine D₂R this article describes searching for group of new ligands for mentioned receptors. In the searching for potentially useful compound, we decided to start from the structure of well-known Fananserin. We tried to developed new derivatives, with changed profile of activity compared to Fananserin. Literature analysis and virtual screening emerged group of halogenated long-chain arylpiperazines derivatives of 1,8 naphthosultam/lactam with hexyl carbon chain to synthesis. The compounds obtaining method was developed with a microwave assisted synthesis. Reactions were carried out in acetonitrile, water or in solvent-free conditions. The obtained compounds were tested for their affinity for the serotonin receptors mentioned above. The work managed to obtain compounds acting on selected serotonin receptors, including multifunctional 5-HT_1A/5-HT₇/D₂ ligand 5k, dual 5-HT_1A/D₂ ligand 5j and selective 5-HT_1A ligands 5r and 5c. The SAR analysis showed a visible dependence of affinity for the 5-HT₆ receptors from structure of ligands. This relationship was discussed using molecular docking methods. A conformal analysis was also performed for selected ligands and the Fukui indexes were calculated using the DFT (B3LYP/6-311+G (d,p) level of theory) methods. The conducted research and analysis using molecular docking methods allows for selecting further pathways of structural modifications in the design of new ligands for serotonin receptors belonging to the group mentioned. What is more, conducted research show the potential using of Fukui indices to predict the biological activity of new molecules.

Keywords: Depression; Fananserin; Fukui; Microwave; Serotonin receptors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antidepressive Agents / chemical synthesis
Antidepressive Agents / chemistry
Antidepressive Agents / pharmacology*
Cyclic S-Oxides / chemical synthesis
Cyclic S-Oxides / chemistry
Cyclic S-Oxides / pharmacology*
Density Functional Theory
Dose-Response Relationship, Drug
Drug Design*
Humans
Ligands
Microwaves
Models, Molecular
Molecular Structure
Naphthalenes / chemical synthesis
Naphthalenes / chemistry
Naphthalenes / pharmacology*
Receptors, Serotonin / metabolism*
Structure-Activity Relationship

Substances

Antidepressive Agents
Cyclic S-Oxides
Ligands
Naphthalenes
Receptors, Serotonin
fananserin